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Secondly, the post-disruption addition of IGF-2 is not a 100% prophylactic treatment in preventing IGF-1/IGFBP re-complexation

At 48 weeks, mean percentage changes in body weight from baseline were approximately: In the 12 mg arm, roughly 100% of participants achieved at least 5% body-weight loss, about 83% reached 15% loss, around 63% achieved 20% loss, and approximately 26% crossed the 25% threshold

Consistent with these immunomodulatory effects, GLP-1 analogs also directly reduce mucin hypersecretion

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